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Analysis of prognostic and predictive factors of response in squamous cell carcinoma using comprehensive biomarker testing

Mélanie Moxhet

May 21, 2021

SCIENTIFIC

In recent years, the diagnosis and treatment of different neoplasms has undergone a great change due to the development of immunotherapy and targeted therapies. Furthermore, the incorporation of massive sequencing techniques (NGS) has made it possible to better understand the molecular profile of tumors and thus, the identification of possible biomarkers related to prognosis and response.

This study focused on a cohort of 13 patients with squamous histology but different topographic locations (7 with lung cancers, 1 with bladder cancer, 1 with cervical cancer, and 1 with head and neck cancer and 2 of origin unknown). The samples were analyzed by NGS with OncoDEEP, our comprehensive biomarker test.

The study demonstrated the impact of molecular alterations analysis on the prognosis, and therapeutic evolution of patients with the aim of integrating clinical and molecular information in a translational oncology study.

The poster "Analysis of prognostic and predictive factors of response in squamous cell carcinoma using NGS techniques" was presented by Patricia Cruz Castellanos, Hospital Universitario La Paz, Madrid, Spain, during the European Lung Cancer Virtual Congress in 2021.