News

- OncoDNA Closes Successful Series B Investment Round
- Feb. 13, 2020
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- OncoDNA’s personalised cancer profiling tests covered by a new insurer
- Nov. 13, 2019
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- COVID-19 PANDEMIC: Delays in cancer surgery due to the pandemic are likely to result in thousands of avoidable deaths. Rebooting cancer diagnostic and treatment pathways must now be a priority for healthcare providers
- June 2, 2020
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- PROSTATE CANCER: Genomic alterations resulting in combined disruption of TP53 and RB1 is associated with poor survival and treatment resistance, but potential vulnerability to PARP + ATR inhibition in preclinical models.
- June 2, 2020
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- BREAST CANCER: The European Medicines Agency's safety committee has recommended updating safety information for hormone replacement therapy (HRT)
- June 2, 2020
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- BREAST CANCER: ER+ PIK3CA mutant breast cancer show worse response to chemo and poorer survival compared with ER+ PIK3CA wild-type
- June 2, 2020
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- LUNG CANCER: MET amplification (≥6 copies) and exon 14 skipping are predictors of response to MET inhibition in NSCLC
- June 2, 2020
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- LUNG CANCER: The use of antibiotics of proton pump inhibitors was associated with worse survival for those receiving immunotherapy, but not for those receiving cytotoxic chemotherapy
- June 2, 2020
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- HAEMATO-ONCOLOGY: Genomic profiling has potential utility in predicting which patients with smouldering myeloma will develop progressive disease
- June 2, 2020
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- CLINICAL TRIALS: From the archives, the 1988 ISIS-2 heart attack trial (n=17,187 subjects) demonstrated the benefits of aspirin therapy, with the exception of those born under Gemini or Libra
- June 2, 2020
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- CHOLANGIOCARCINOMA A small single arm study of PD-1 inhibition (nivolumab) for previously treated biliary tract cancers showed ORR 11%
- May 26, 2020
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- HEPATOCELLULAR CANCER Combination PD-L1 and VEGFR inhibition (atezolizumab plus bevacizumab) delivered better overall and progression-free survival than standard of care sorafenib in a pivotal phase 3 study.
- May 26, 2020
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- MELANOMA: In a retrospective study of patients with advanced disease who achieved a complete response to immunotherapy, cessation of therapy was associated with a 27% risk of subsequent disease progression.
- May 26, 2020
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- PROSTATE CANCER The FDA have granted accelerated approval to the PARP inhibitor rucaparib for BRCA-mutated (germline or somatic) metastatic castrate-resistant disease.
- May 26, 2020
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- PROSTATE CANCER: A PROTAC-based androgen receptor degrader has shown anti-tumour activity in first in human studies presented at ASCO.
- May 26, 2020
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- DRUG TARGETS: KRAS Disappointing results from ASCO of the KRAS G12C inhibitor (AMG-510), with a study in colorectal cancer and a basket study of non-NSCLC/CRC indications both delivering ORR 12%.
- May 26, 2020
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- DRUG TARGETS: MET A phase I study of an anti-MET antibody (telisotuzumab) in advanced cancers reported partial responses in MET amplified tumours
- May 26, 2020
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- GERMLINE PREDISPOSITION: A study of 1,507 children, adolescents and young adults with cancer found pathogenic/likely pathogenic germline cancer predisposition alleles in 12%
- May 18, 2020
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- LUNG CANCER: Early data from a small (n=109) randomised trial suggest the addition of allogenic NK cells (KIR mismatched) to PD-1 inhibition (pembrolizumab) improves outcomes in PD-L1+ (≥1%) NSCLC (OS 15.5 months versus 13.3 months)
- May 18, 2020
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- BREAST CANCER: The prevalence of CHEK2 germline pathogenic variants was 2.3% in this 2,344 participant study; CHEK2 variants were associated with ER+ disease and worse overall survival
- May 18, 2020
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- CHOLANGIOCARCINOMA: PD-L1 + MEK inhibition improved PFS versus PD-L1 alone in the second/third line setting
- May 18, 2020
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- CLINICAL TRIALS: The use of surrogate end-points has the potential to expedite approval of efficacious drugs
- May 18, 2020
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- DRUG TARGETS, RET in LUNG/THYROID CANCER: The FDA have granted accelerated approval for the RET inhibitor selpercatinib for RET fusion positive NSCLC, medullary thyroid cancer and radioactive iodine-refractory thyroid cancer.
- May 18, 2020
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- DRUG TARGETS, ERBB2: A small (n=60) basket study of trastuzumab deruxtecan in ERBB2 (HER2) expressing/mutated tumours reported ORR 28%
- May 18, 2020
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- DRUG TARGETS, BRAF: A basket study (n=172) of vemurafenib in assorted BRAF V600-mutant tumours reported ORR 33%, with responses seen in 13 different tumour histologies.
- May 18, 2020
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- CLINICAL UTILITY OF GENOMIC PROFILING: A study of testicular cancer has highlighted the utility of genomics by demonstrating how complex genomic signatures can be used to predict response to chemotherapy
- May 18, 2020
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- 47% of cancer overall positive response to treatment thanks to OncoDEEP combined tumour molecular profiling
- May 11, 2020
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- EARLY CANCER DETECTION: Data from GRAIL presented at AACR indicate continued progress in the development of a methylation-based ctDNA assay with high specificity for the early detection of cancer.
- May 11, 2020
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- PANCREATIC CANCER: Addition of a PARP inhibitor (veliparib) to gemcitabine + cisplatin chemo did not improve outcomes for patients harbouring germline mutations in BRCA1/2 or PALB2.
- May 11, 2020
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- MELANOMA: The addition of PD-L1 blockade (atezolizumab) to combined BRAF/MEK inhibition (vemurafenib + cobimetinib) improved PFS as first line therapy in advanced BRAF V600 mutant melanoma. Survival data are awaited.
- May 11, 2020
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- GASTRIC/COLORECTAL CANCER: Promising early efficacy data for combined regorafenib plus nivolumab: ORR 44% and 36% for gastric and colorectal respectively, all bar one with microsatellite stable disease.
- May 11, 2020
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- CHOLANGIOCARCINOMA: Phase 2 data now published supporting the FDA's recent approval of pemigatinib for previously treated advanced FGFR2-rearranged tumours (ORR 36%). Responses were not seen in subjects with other FGF/FGFR alterations
- May 11, 2020
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- LUNG CANCER: Data from TRACERx presented at AACR provides further support for the use of personalised ctDNA assays in the assessment of minimal residual disease and impending progression following surgery for early stage disease.
- May 11, 2020
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- LUNG CANCER: The FDA have approved the MET inhibitor capmatinib for advanced NSCLC harbouring MET exon 14 skipping. Approval is based on ORR of 68% and 41% for treatment-naive and previously treated patients, respectively.
- May 11, 2020
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- IMMUNOTHERAPY 29% of patients with immune-related side-effects requiring therapy cessation experienced recurrence of the same SE on rechallenge.
- May 4, 2020
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- DRUG TARGETS Disappointing results from NCI-MATCH where the MEK inhibitor trametinib failed to impact cancers harbouring non-V600 BRAF mutations (ORR 3%).
- May 4, 2020
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- ENDOMETRIAL CANCER: Normal endometrial glands frequently harbour pathogenic somatically-acquired mutations in cancer genes, suggesting that the processes leading to cancer are initiated early in life.
- May 4, 2020
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- BREAST CANCER: The FDA have granted accelerated approved to the anti-TROP2 antibody-drug conjugate sacituzumab govitecan for patients with triple negative disease.
- May 4, 2020
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- Loss of CDK12 as a marker of aggressive disease likely to metastasise, but with higher response rates to checkpoint inhibition
- May 4, 2020
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- PROSTATE CANCER: Structural variants resulting in rearrangement of the androgen receptor (AR) are frequent and may be a marker of resistance to endocrine therapy.
- May 4, 2020
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- PROSTATE CANCER: Coexisting loss of BRCA2 and RB1 is associated with aggressive clinical behaviour in prostate cancer, and possibly also in other cancer types.
- May 4, 2020
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- COVID-19: A fall in the number of people being diagnosed with cancer in recent weeks has been reported in several countries,
- May 4, 2020
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- DRUG TARGETS: IMMUNOTHERAPY - Establishing guidelines to harmonize tumor mutational burden (TMB): in silico assessment of variation in TMB quantification across diagnostic platforms
- April 27, 2020
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- DRUG TARGETS: NTRK - The UK regulator NICE has approved the use of larotrectinib for patients with advanced NTRK fusion position solid tumours, in both adults and children.
- April 27, 2020
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- COLORECTAL CANCER: A small neoadjuvant study reported responses to combined PD-L1 + CTLA-4 blockade in both MSI+ (100% pathological response, 95% MPR) and MSI-negative (27% pathological response, 20% MPR) tumours.
- April 27, 2020
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- BREAST CANCER: Alterations in PTEN and ESR1 promote clinical resistance to alpelisib plus aromatase inhibitors
- April 27, 2020
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- BREAST CANCER: Updated ASCO/CAP guidelines for oestrogen receptor testing highlight the weak positive group (1-10% ER+ tumour cells) as requiring specific pathways for laboratory confirmation and discussion of therapeutic options
- April 27, 2020
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- ENDOMETRIAL CANCER: Data from SGO 2020 indicate survival benefit for the addition of trastuzumab to standard chemo for those with advanced ERBB2-expressing (HER2+) disease (OS 24.4 versus 29.6 months)
- April 27, 2020
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- CHOLANGIOCARCINOMA: FGFR2 fusions appear to be much less frequent in tumours arising in the context of chronic liver fluke infection, the most common aetiology in SE Asia.
- April 27, 2020
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- CHOLANGIOCARCINOMA: The FDA have granted accelerated approval to the FGFR inhibitor pemigatinib for previously treated patients with advanced FGFR2-rearranged tumours. The pivotal clinical trial showed ORR 36% for this agent.
- April 27, 2020
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- BREAST CANCER : The broad spectrum kinase inhibitor lucitanib (VEGFR1-3, FGFR1-3 & PDGFRα/β) showed modest efficacy in FGFR1 amplified HR+ disease, delivering ORR 19%, at the cost of hypertension-related toxicity.
- April 20, 2020
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- PANCREATIC CANCER : In a real-world study, 28% of patients harboured actionable genomic variants, of whom 24% received molecularly matched therapy. Receipt of matched therapy was associated with longer OS (2.6 versus 1.5 years).
- April 20, 2020
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- COLORECTAL CANCER : The FDA have approved combination therapy targeting BRAF and EGFR (encorafenib + cetuximab) for metastatic BRAF V600E mutant colorectal cancer which has previously been treated.
- April 20, 2020
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- COVID-19 PANDEMIC: The American Society of Clinical Oncology (ASCO) has launched a registry to gather information on disease severity and outcomes for cancer patient
- April 20, 2020
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- CANCER SCREENING & EARLY DETECTION: A methylation based ctDNA assay from GRAIL delivered sensitivity 93% for stage IV cancer, falling to 43% for stage II and 18% for stage I disease
- April 14, 2020
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- NTRK FUSIONS: A pooled analysis of 3 clinical trials (n=50 total subjects) indicated ORR 79% for the NTRK inhibitor larotrectinib, with 16% CR
- April 14, 2020
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- MELANOMA Protein kinase C is being explored as a drug target in uveal melanoma, where it is activated by upstream mutations in GNAQ/GNA11
- April 14, 2020
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- BREAST CANCER: Real-world data from the GENIE consortium suggest a benefit for MTOR inhibition where tumours harbour an AKT E17K mutation.
- April 14, 2020
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- CNS CANCER: Evolution of mismatch repair deficiency renders glioblastoma resistant to temozolomide (TMZ)
- April 14, 2020
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- SARCOMA: The oncolytic virus T-VEC in combination PD-1 blockade (pembrolizumab) delivered ORR 35% in advanced sarcoma (Phase 2, n=20 subjects). Further development is planned.
- April 6, 2020
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- BREAST CANCER: Association of Germline Variant Status With Therapy Response in High-risk Early-Stage Breast Cancer
- April 6, 2020
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- LUNG CANCER: Targeting HER2 with Trastuzumab Deruxtecan: A Dose-Expansion, Phase I Study in Multiple Advanced Solid Tumors
- April 6, 2020
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- LUNG CANCER: The FDA have granted breakthrough designation to an EGFR-MET bispecific antibody from Janssen, for the treatment of NSCLC harbouring an EGFR exon 20 insertion mutation.
- April 6, 2020
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- LUNG CANCER: A meta-analysis of osimertinib treatment for brain metastasis reported CNS ORR 64%.
- April 6, 2020
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- OVARIAN CANCER: All-comer testing of tumour (FFPE) tissue for BRCA1/2 mutations reported a pickup rate of 17% for pathogenic variants; follow-up germline testing revealed mutations to be 57% inherited and 43% somatic.
- April 6, 2020
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- COLORECTAL CANCER: The addition of cetuximab to perioperative chemotherapy resulted in worse overall survival compared with chemo alone in KRAS wild-type patients with resectable/suboptimally resectable liver metastases.
- March 30, 2020
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- COLORECTAL CANCER: Colorectal cancer statistics, 2020
- March 30, 2020
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- SARCOMA: Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in Patients With Osteosarcoma
- March 30, 2020
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- LUNG CANCER: Combination MET + EGFR inhibition (osimertinib + savolitinib) delivered ORR 48-64% in EGFR-mutant, MET-amplified subjects who had progressed on prior anti-EGFR therapy.
- March 30, 2020
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- LUNG CANCER: Real-world data suggests osimertinib is associated with a 5% risk of cardiac adverse events. This drug has previously been linked to QT prolongation, cardiomyopathy and heart failure.
- March 30, 2020
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- COVID-19 PANDEMIC : ASCO have released guidance on dealing with the impact of the pandemic on the delivery of cancer care.
- March 30, 2020
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- COVID-19 PANDEMIC : Whether the pandemic represents a specific risk to cancer patients is currently unclear.
- March 24, 2020
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- Prevalence of Pathogenic Variants in Cancer Susceptibility Genes Among Women With Postmenopausal Breast Cancer
- March 24, 2020
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- GERMLINE PREDISPOSITION : Tumour-only sequencing detects both inherited and acquired variants, mandating germline testing in appropriate cases.
- March 24, 2020
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- BREAST CANCER: The design of patient-specific ctDNA assays for the detection of minimal residual disease (MRD), based on whole exome sequencing of the primary tumour, significantly increased the detection sensitivity for MRD+ patients
- March 24, 2020
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- HEPATIC CANCER FDA: grants accelerated approval to nivolumab and ipilimumab combination for hepatocellular carcinoma
- March 24, 2020
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- DRUG RESISTANCE: In vitro preclinical studies identified BRCA2 amplification as a potential mechanism of PARP inhibitor resistance in BRCA2 mutant cancer cell lines.
- March 16, 2020
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- CANCER SCREENING AND EARLY DETECTION: Evaluating the Use of Circulating MicroRNA Profiles for Lung Cancer Detection in Symptomatic Patients
- March 16, 2020
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- B-CELL LYMPHOMA: Durable Remission Following “Off-the-Shelf” Chimeric Antigen Receptor (CAR) T-Cells in Patients with Relapse/Refractory (R/R) B-Cell Malignancies
- March 16, 2020
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- PANCREATIC CANCER: An Emerging Paradigm for Germline Testing in Pancreatic Ductal Adenocarcinoma and Immediate Implications for Clinical Practice
- March 16, 2020
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- COLORECTAL CANCER: Mutations in TP53 and RAS/BRAF show utility as prognostic markers, with co-mutated tumours showing the worst outcomes.
- March 16, 2020
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- Multi-targeted CRISPR-based genome engineering has been used to successfully generate adoptive anti-cancer T cells. The T cells express an NY-ESO-1 transgene alongside deletion of both PD-1 and the endogenous T cell receptor.
- March 9, 2020
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- CLINICAL TRIALS AND DRUG TARGETS: CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
- March 9, 2020
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- CLINICAL TRIALS AND DRUG TARGETS: Oncology indications are set to dominate the landscape in 2020, accounting for 32% of all new trials.
- March 9, 2020
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- MELANOMA: Two noteworthy biomarker studies identified assessment of T cell infiltrate and clonality as a predictor of subsequent metastasis in early stage disease.
- March 9, 2020
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- BREAST CANCER: FDA approves neratinib for metastatic HER2-positive breast cancer
- March 9, 2020
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- BREAST CANCER: Adjuvant cisplatin was not superior to doxorubicin-cyclophosphamide at inducing pathological CR for patients with BRCA1/2 mutant disease in a small cohort (n=117).
- March 9, 2020
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- LUNG CANCER: A study of patients with locally advanced NSCLC identified potential utility for personalised ctDNA-based MRD detection in guiding the use of consolation immunotherapy.
- March 9, 2020
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- DRUG TARGETS: The heat shock protein 90 inhibitor ganetespib failed to improve outcomes when added to chemotherapy in advance NSCLC (phase III GALAXY-2 trial). Samples were obtained for biomarker studies; results not yet reported.
- March 2, 2020
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- PHARMACOGENOMICS: The FDA have published a provisional list of PGx markers with potential utility in clinical practice, and are inviting comments from the community.
- March 2, 2020
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- BREAST CANCER: ARID1A loss of function was identified as a marker of resistance to hormone therapy and of sensitivity to BET inhibition in this study of preclinical models and patient samples.
- March 2, 2020
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- BREAST CANCER: RB1 loss by IHC was associated with sensitivity to the TOPO 1 inhibitor irinotecan in a preclinical TNBC model. Confirmation of this association in patient samples would be a useful next step.
- March 2, 2020
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- BLADDER CANCER: Durvalumab Plus Olaparib Combo Shows 50% Pathologic Complete Response in MIBC
- Feb. 24, 2020
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- LUNG CANCER: FDA Grants Priority Review to NDA for Capmatinib in MET Exon 14+ NSCLC
- Feb. 24, 2020
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- MELANOMA CTLA-4 inhibition (ipilimumab) improved overall survival compared with interferon in the adjuvant setting. A higher dose of ipilimumab (10 mg/kg versus 3 mg/kg) produced more adverse events but did not further improve outcome
- Feb. 24, 2020
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- PROSTATE CANCER: Combined PD-L1 and multi-kinase inhibition (atezolizumab + cabozantinib) produced ORR 32% in a small (n=44) study of metastatic castrate-resistant disease; two subjects achieved CR (COSMIC-021 trial, ASCO GU 2020).
- Feb. 24, 2020
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- BREAST CANCER: 53% of patients receiving neoadjuvant PARP inhibition (talazoparib) achieved complete pathological response in this small (n=20) study of germline BRCA1/2 mutant patients. A larger trial is underway.
- Feb. 24, 2020
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- CERVICAL CANCER: Impact of HPV vaccine hesitancy on cervical cancer in Japan: a modelling study
- Feb. 24, 2020
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- LUNG CANCER: Osimertinib demonstrated efficacy in EGFR-mutant NSCLC with CNS metastasis, delivering 62% CNS ORR in a small (n=41) study.
- Feb. 24, 2020
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- GERMLINE CANCER PREDISPOSITION: Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness
- Feb. 17, 2020
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- LYMPHOMA: A phase 1/2 trial of anti-CD19 CAR transduced natural killer (CAR-NK) cells demonstrated efficacy in lymphoid malignancy without the CNS side-effects or production complexity of CAR-T approaches.
- Feb. 17, 2020
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- COLORECTAL CANCER: A giant inflatable colon has been deployed by a team in the Lebanon to raise cancer awareness and encourage participation in screening programmes. Positive outcomes were reported.
- Feb. 17, 2020
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- LUNG CANCER: Studies of patient biopsies and preclinical models imply that activating EGFR mutations drive an immunosuppressive tumour microenvironment, and suggest synergy for combination EGFR/PD-1 inhibition.
- Feb. 17, 2020
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- ENDOMETRIAL CANCER: The combination of everolimus, letrozole and metformin delivered OR 28% (all PR) in pretreated patients in this small (n=54) phase II study.
- Feb. 17, 2020
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- LUNG CANCER: Unsurprisingly, bronchial cells from smokers harbour more frequent mutations than non-smokers; reassuringly, quitting smoking allows replenishment of the lung epithelium by quiescent cells with lower mutational burden.
- Feb. 10, 2020
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- LUNG CANCER: Screening current and former smokers by CT scanning reduced lung cancer mortality by 0.8 deaths per 1,000 person-years in a Dutch study with 10 years follow up.
- Feb. 10, 2020
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- BREAST CANCER: Whilst high dose chemo with blood stem cell rescue is ineffective in advanced disease (and mired in scandal following the misconduct of Bezwoda and colleagues in the 1990's), this approach may benefit high-risk patients
- Feb. 10, 2020
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- BREAST CANCER: Preclinical and patient studies have identified loss of either RB1 or PTEN as mechanisms of resistance to CDK4/6 inhibitors such as palbociclib. PTEN loss also confers resistance to PI3K inhibitors such as taselisib.
- Feb. 10, 2020
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- BREAST CANCER: Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers
- Feb. 10, 2020
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- BREAST CANCER: A small study identified somatic ATM mutation as a predictor of response to radiotherapy. This association is in keeping with known ATM pathway biology and warrants further study.
- Feb. 10, 2020
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- DRUG TARGETS: A new front has been opened in the battle to inhibit oncogenic RAS signalling, through the use of cell-penetrating antibody technology
- Feb. 3, 2020
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- CANCER AETIOLOGY: An estimated 13% of cancer globally is caused by infection, the most common agents being Helicobacter pylori, human papillomavirus and hepatitis B & C viruses
- Feb. 3, 2020
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- COLORECTAL CANCER: The combination of encorafenib, binimetinib and cetuximab (triple therapy) improved survival in BRAF V600E mutant disease with manageable toxicity and minimal impact on quality of life
- Feb. 3, 2020
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- PANCREATIC CANCER: The combination of cisplatin and gemcitabine with or without veliparib produced impressive response rates (65-75%) in patients with germline BRCA/PALB2 mutation
- Feb. 3, 2020
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- HEPATOCELLULAR CANCER: The combination of nivolumab, ipilimumab and cabozantinib delivered an objective response rate of 31%, including complete remissions, in sorafenib-treated patients.
- Feb. 3, 2020
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- IMMUNOTHERAPY Three studies have identified tumour B-cell infiltration as an independent marker of response to check-point inhibition therapy.
- Jan. 27, 2020
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- BREAST CANCER: Several new anti-HER2 agents on the horizon
- Jan. 27, 2020
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- LUNG CANCER: The addition of chemotherapy to EGFR inhibitor therapy improved survival in advanced EGFR-mutant NSCLC in two independent studies, compared with targeted therapy alone
- Jan. 27, 2020
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- PROSTATE CANCER: The FDA have granted priority review for the PARP inhibitor rucaparib in the mCRPC setting, based on data from the phase II TRITON2 trial which showed ORR 43.9% for BRCA1/2 mutation carriers.
- Jan. 27, 2020
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- LUNG CANCER: The FDA have granted priority review for combination nivolumab/ipilimumab (anti-PD-1/CTLA-4) as first line in advanced NSCLC (EGFR/ALK wt)
- Jan. 27, 2020
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- LUNG CANCER: Crizotinib delivered objective response rates of 32% in a phase I study of NSCLC harbouring MET exon 14 skipping, most of whom (62%) had received prior therapy.
- Jan. 27, 2020
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- LUNG CANCER: Despite early encouraging results, the EGFR inhibitor poziotinib failed to meet its primary endpoint in the phase II ZENITH20 tria
- Jan. 21, 2020
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- COLORECTAL CANCER: The FDA have approved the kinase inhibitor avapritinib for patients with metastatic gastrointestinal stromal tumour (GIST) harbouring a PDGFRA exon 18 mutation
- Jan. 20, 2020
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- LUNG CANCER: Correcting for tumour cellularity can improve the power of tumour mutational burden to identify immunotherapy responders
- Jan. 20, 2020
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- PERSONALISED MEDICINE: In 2018, an estimated 40% of new drugs approved by the FDA were considered personalised medicines; this is expected to exceed 50% this year.
- Jan. 14, 2020
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- IMMUNOTHERAPY: Meta-analysis suggests that anti-PD-1 delivers superior survival gains to anti-PD-L1. This is in keeping with current understanding of disease biology.
- Jan. 14, 2020
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- DRUG TARGETS: Another VEGFR inhibitor study fails to improve overall survival despite longer progression free survival at interim analysis (ramucirumab, urothelial cancer).
- Jan. 14, 2020
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- BREAST CANCER: New data from IMpassion130 confirm first interim analysis- addition of atezolizumab (aPD-L1) to nab-paclitaxel improved survival in advanced TNBC only where infiltrating immune cells express PD-L1
- Jan. 14, 2020
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- BREAST CANCER Despite preclinical data identifying oncogenic RANK pathway activation, the RANK ligand inhibitor denosumab failed to improve outcomes in the neoadjuvant or adjuvant settings.
- Jan. 14, 2020
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- COLORECTAL CANCER: Recent work in colorectal cancer supports a role for ctDNA methylation patterns as a tumour-specific marker.
- Jan. 6, 2020
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- GERMLINE CANCER: PREDISPOSITION An international 524 family study of pathogenic PALB2 variants identified increased risk of developing breast, ovarian and pancreatic cancers.
- Jan. 6, 2020
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- HEPATOCELLULAR CANCER: The FGFR4 inhibitor fisogatinib produced ORR 17% for FGF19+ tumours (IHC); responses were not seen in FGF19-negative cases. Resistance was associated with the appearance of gatekeeper mutations.
- Jan. 6, 2020
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- COLORECTAL CANCER: Response to Anti-EGFR Therapy in Patients with BRAF non-V600–Mutant Metastatic Colorectal Cancer
- Jan. 6, 2020
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- MELANOMA: Ipilimumab (anti-CTLA-4) improved survival compared to interferon in the adjuvant setting.
- Jan. 6, 2020
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- LUNG CANCER: Overweight patients achieve better responses to checkpoint inhibition.
- Jan. 6, 2020
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- BREAST CANCER: Conflicting results of neoadjuvant immunotherapy for TNBC, (PD-1 inhibitor pembrolizumab vs atezolizumab)
- Dec. 30, 2019
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- PANCREATIC CANCER: An FDA panel will recommend approval of olaparib as maintenance for patients with platinum sensitive/stable disease, based on data from the POLO trial.
- Dec. 30, 2019
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- LUNG CANCER: The kinase inhibitor crizotinib produced ORR 27% for patients with MET exon 14 skipping or amplification in a small (n=26) early phase study
- Dec. 30, 2019
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- CLINICAL TRIALS: Patients enrolled in therapeutic trials for the most common cancer types are on average 6.5 years younger than the incident population
- Dec. 30, 2019
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- CANCER HETEROGENEITY: Longitudinal molecular trajectories of diffuse glioma in adults
- Dec. 23, 2019
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- COLORECTAL CANCER: Genomic Profiling for KRAS, NRAS, BRAF, Microsatellite Instability, and Mismatch Repair Deficiency Among Patients With Metastatic Colon Cancer
- Dec. 23, 2019
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- BREAST CANCER: ACMG have issued guidance against testing all patients with breast cancer for inherited predisposition; rather, they favour careful case-by-case assessment of risk
- Dec. 23, 2019
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- BREAST CANCER: NSABP B-47/NRG Oncology Phase III Randomized Trial Comparing Adjuvant Chemotherapy With or Without Trastuzumab in High-Risk Invasive Breast Cancer Negative for HER2 by FISH and With IHC 1+ or 2+
- Dec. 23, 2019
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- BREAST CANCER: Two new agents show promising clinical results in HER2+ disease: trastuzumab deruxtecan, an antibody-drug conjugate, and tucatinib, a small molecule inhibitor.
- Dec. 23, 2019
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- Immune editing (resulting in loss of neoantigens) has been suggested as a mechanism of tumour immune escape.
- Dec. 20, 2019
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- A small NCI-MATCH study of PD-1 inhibition (nivolumab) in non-CRC MSI+ tumours showed ORR 36%.
- Dec. 20, 2019
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- IMMUNOTHERAPY Single agent pembrolizumab (aPD-1) failed its primary OS/PFS end-point in a phase 3 trial of previously treated hepatocellular cancer, and showed minimal activity (3-5% ORR) in treatment refractory prostate cancer.
- Dec. 20, 2019
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- MELANOMA Pre-clinical work suggests potential utility of combined BRAF/MEK inhibition for BRAF wild-type, NRAS mutant melanoma.
- Dec. 20, 2019
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- LYMPHOMA: Several studies from ASH reported significant activity and impressive response rates for different bispecific antibodies (mainly CD3 and CD19 or CD20).
- Dec. 16, 2019
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- PANCREATIC CANCER The FDA will discuss this month an application for approval of the PARP inhibitor olaparaib as maintenance therapy for patients with BRCA-mutant cancer post upfront chemotherapy.
- Dec. 16, 2019
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- CERVICAL CANCER: A vision for the global elimination of cervical cancer through systematic international vaccination programmes.
- Dec. 16, 2019
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- UROTHELIAL CANCER: Pathogenic or likely pathogenic germline variants were found in 14% of patients with bladder cancer, mainly in DNA damage response genes.
- Dec. 16, 2019
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- CHOLANGIOCARCINOMA The FDA have granted priority approval review of pemigatinib for patients harbouring FGFR2 fusions.
- Dec. 9, 2019
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- MELANOMA Neoadjuvant administration of the oncolytic virus T-VEC improved OS in advanced melanoma.
- Dec. 9, 2019
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- COLORECTAL CANCER: Integrated biomarker analysis of a large patient cohort highlights fibroblast and CD8+ lymphocyte infiltration as predictive variables.
- Dec. 9, 2019
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- LUNG CANCER: New drugs targeting EGFR (lazertinib) and ALK/ROS1 (lorlatinib) have shown efficacy in phase 1/2 trials in NSCLC.
- Dec. 9, 2019
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- IMPROVED SURVIVAL? The addition of VEGF inhibition to EGFR inhibition for patients with EGFR-mutant NSCLC delivered improved PFS in a phase 3 RCT...
- Dec. 9, 2019
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- LUNG CANCER Patients with very high PD-L1 expression (>90%) show particularly good response to PD-1 inhibition compared to lower expressing tumours.
- Dec. 9, 2019
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- HEPATOCELLULAR CANCER A novel small molecule targeting the FGF19-FGFR4 axis has entered early clinical trial in hepatic and other cancers
- Dec. 9, 2019
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- VEGF as a therapeutic target The VEGF-A inhibitor bevacizumab is approved in 11 cancer types, but has failed to improve overall survival in 9 of these.
- Dec. 2, 2019
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- COLORECTAL CANCER: Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability–High/Mismatch Repair–Deficient Metastatic Colorectal Cancer: KEYNOTE-164
- Dec. 2, 2019
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- HEAD & NECK CANCER: In the phase 3 KEYNOTE-048 trial, pembrolizumab (aPD-1) plus chemotherapy was superior as first line therapy to cetuximab plus chemotherapy in patients with metastatic or locally incurable recurrent disease, regard
- Dec. 2, 2019
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- CNS CANCER: Phase I clinical data from patients with low grade glioma receiving vorasidenib or vosidenib confirm early suggestions of efficacy.
- Dec. 2, 2019
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- LUNG CANCER: Overall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC
- Dec. 2, 2019
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- IMMUNOTHERAPY: Risk of Immunotherapy Related Toxicity in Patients with Rheumatoid Arthritis
- Nov. 25, 2019
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- RENAL CANCER: Clinical Validation of PBRM1 Alterations as a Marker of Immune Checkpoint Inhibitor Response in Renal Cell Carcinoma
- Nov. 25, 2019
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- LUNG CANCER: Osimertinib versus Comparator EGFR Tyrosine Kinase Inhibitor as First-Line Treatment in Patients with EGFR-Mutated Advanced Non–Small Cell Lung Cancer
- Nov. 25, 2019
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- MELANOMA: Extended 5-Year Follow-up Results of a Phase Ib Study (BRIM7) of Vemurafenib and Cobimetinib in BRAF-Mutant Melanoma
- Nov. 25, 2019
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- Efficacy of Pembrolizumab in Patients With Noncolorectal High MSI/Mismatch Repair–Deficient Cancer
- Nov. 18, 2019
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- Glioblastoma Multiforme: 80% 6-Month Progression-Free Survival In Phase 2 Study with INO-5401 In Combination with PD-1 Inhibitor (cemiplimab)
- Nov. 18, 2019
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- PROSTATE CANCER: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers
- Nov. 18, 2019
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- Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor
- Nov. 18, 2019
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- BREAST CANCER: Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors
- Nov. 18, 2019
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- International Alliance for Cancer Early Detection
- Nov. 12, 2019
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- Mirati Therapeutics Presents First Clinical Data Of Phase 1/2 Trial Of MRTX849 At The 2019 AACR-NCI-EORTC International Conference On Molecular Targets And Cancer Therapeutics
- Nov. 12, 2019
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- DCCC Danish circulating tumor DNA network (DCCC ctDNA)
- Nov. 12, 2019
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- FGFR1 Amplification Mediates Endocrine Resistance but Retains TORC Sensitivity in Metastatic Hormone Receptor–Positive (HR+) Breast Cancer
- Nov. 12, 2019
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- Outcomes in Patients With Pancreatic Adenocarcinoma With Genetic Mutations in DNA Damage Response Pathways: Results From the Know Your Tumor Program
- Nov. 12, 2019
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- The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
- Nov. 12, 2019
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- Gefitinib Alone Versus Gefitinib Plus Chemotherapy for Non–Small-Cell Lung Cancer With Mutated Epidermal Growth Factor Receptor: NEJ009 Study
- Nov. 12, 2019
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- The EGFR Exon 19 Mutant L747-A750>P Exhibits Distinct Sensitivity to Tyrosine Kinase Inhibitors in Lung Adenocarcinoma
- Nov. 12, 2019
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- Multidimensional imaging provides evidence for down-regulation of T cell effector function by MDSC in human cancer tissue
- Nov. 4, 2019
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- Analysis of the Association Between Adverse Events and Outcome in Patients Receiving a Programmed Death Protein 1 or Programmed Death Ligand 1 Antibody
- Nov. 4, 2019
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- Pembrolizumab with carboplatin and paclitaxel for untreated metastatic squamous non-small-cell lung cancer
- Nov. 4, 2019
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- Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity
- Nov. 4, 2019
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- Targeting ERBB2 (HER2) Amplification Identified by Next-Generation Sequencing in Patients With Advanced or Metastatic Solid Tumors Beyond Conventional Indications
- Nov. 4, 2019
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- Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses
- Nov. 4, 2019
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- Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection
- Nov. 4, 2019
- read more
- Three early stage clinical trials have suggested benefit of adding checkpoint inhibition to BRAF ± MEK inhibitor therapy for patients with advanced BRAF-mutant disease.
- Oct. 21, 2019
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- A trial looking at avelumab and chemotherapy for bowel cancer (POLEM)
- Oct. 21, 2019
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- Durvalumab With or Without Tremelimumab for Patients With Metastatic Pancreatic Ductal Adenocarcinoma
- Oct. 21, 2019
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- New Studies Question Whether Novel Anti-Cancer Drugs Are Worth Their Extra Cost
- Oct. 14, 2019
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- LOXO-292 Demonstrates Promising Anti-Tumour Activity in RET-Altered Thyroid Cancer
- Oct. 14, 2019
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- A Cost-effectiveness Analysis of Multigene Testing for All Patients With Breast Cancer
- Oct. 14, 2019
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- Pivotal Trial of Enfortumab Vedotin in Urothelial Carcinoma After Platinum and Anti-Programmed Death 1/Programmed Death Ligand 1 Therapy
- Oct. 14, 2019
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- Safety and Efficacy of T-DM1 Plus Neratinib in Patients With Metastatic HER2-Positive Breast Cancer: NSABP Foundation Trial FB-10
- Oct. 14, 2019
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- Targeted Therapy in Advanced Melanoma With Rare BRAF Mutations
- Oct. 14, 2019
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- Breast Cancer: inactivating NF1 mutations are enriched in advanced BC and contribute to endocrine therapy resistance
- Oct. 7, 2019
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- Drug targets. - Not all BRAF mutations are equal, falling into 3 different classes based on mechanism of action and therapeutic sensitivity
- Oct. 4, 2019
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- Breast cancer. -Retrospective data suggest a role for mammography screening for high risk males
- Oct. 4, 2019
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- Prostate cancer. -Amplification of the androgen receptor (AR) detected by ctDNA analysis is associated with poor response to anti-androgen therapy
- Oct. 4, 2019
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- Lung Cancer: 3 key news from ESMO on atezolizumab (aPD-L1), Osimertinib 7 months extra survival, conflicting view on TMB
- Oct. 4, 2019
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- Cholangiocarcinoma. - One third of patients with FGFR2 rearrangements showed response to targeted anti-FGFR therapy (pemigatinib) in the second line (post-chemo) setting.
- Oct. 4, 2019
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- Ovarian cancer: 3 randomised controlled phase III clinical trials presented at ESMO establish the benefit of PARP inhibition ...
- Oct. 3, 2019
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- OVARIAN CANCER: Maintenance therapy with the PARP inhibitor niraparib improved progression free survival; it also increased the amount of time patients were without symptoms.
- Sept. 16, 2019
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- The FDA have issued a warning of rare but potentially severe lung inflammation associated with CDK4/6 inhibitor therapy (palbociclib, ibociclib, abemaciclib).
- Sept. 13, 2019
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- The European Medicines Agency has followed the FDA's lead by granting tissue agnostic approval to the NTRK inhibitor larotrectinib for patients with NTRK-fusion cancers.
- Aug. 5, 2019
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COVID-19 AND CANCER: Supporting oncologists by providing free OncoKDM access

April 14, 2020Read more

SCIENTIFIC

COVID-19 PANDEMIC: Delays in cancer surgery due to the pandemic are likely to result in thousands of avoidable deaths. Rebooting cancer diagnostic and treatment pathways must now be a priority for healthcare providers

June 2, 2020Read more

SCIENTIFIC

PROSTATE CANCER: Genomic alterations resulting in combined disruption of TP53 and RB1 is associated with poor survival and treatment resistance, but potential vulnerability to PARP + ATR inhibition in preclinical models.

June 2, 2020Read more

SCIENTIFIC

BREAST CANCER: The European Medicines Agency's safety committee has recommended updating safety information for hormone replacement therapy (HRT)

June 2, 2020Read more

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