MONCODANEUM: A game-changing project in cancer precision medicine

Join the "Hôpitaux Universitaires de Strasbourg", the Oncology Center of Bydgoszcz and other major cancer centers in Belgium, Luxembourg, the Netherlands and Spain in this global project !

Discover How Your Cancer Data Can Be Turned into Knowledge Driven Medicine

It has become quite complex for healthcare professionals to define the best treatment and monitoring strategies given all the data generated by the analysis of the tumor and other markers. In addition, biologists and lab managers who are in charge of the technological platforms are also facing difficulties with the flood of data and their proper integration and interpretation. This is where the Moncodaneum Project comes in. Its objective is to integrate and interpret all the tumor information, such as DNA/RNA sequencing data, IHCs analyses, methylation … that are influencing clinical decisions, taking into consideration cost, time and ergonomic constraints and, ultimately, utility for the oncologist.

 

Why should you consider participating ?

  • Because turning big data into clinically useful treatment recommendations is the future of precision medicine and you want to be at the forefront of cutting-edge medical technology
  • Because you are running NGS panels (and perhaps additional testing) and you need an innovative, integrative solution to translate, interpret and visualize your results easily and rapidly, at the same time respecting the highest quality standards.
  • Because the project has an international dimension and is a unique opportunity to share expertise and know-how and exchange best practices, while keeping up to date with the latest scientific innovations.
  • And last but not least, because your participation in the project will be covered by OncoDNA and all  the data from your samples will be analyzed free of charge.

If you want to join this innovative project or if you have any questions about it, please contact the project leader at jf.laes@oncodna.com. You can also try out our software at www.oncokdm.com for free.

Objectives of the project

Moncodaneum with a total investment of € 10 million is partially financed by the Walloon Region of Belgium. The main goal of the project is to connect major cancer treatment centers worldwide to OncoKDM so that they can benefit from its powerful interpretation algorithms and innovative reporting.  Pilot projects are already under way, in particular with the SOLTI Group in Spain.

How innovative is Moncodaneum ?

The innovative traits of this project consist of applying the notion of “Single patient clinical trial”. This fits in with the evolution of  “personalized” medicine towards  “precision” medicine. In the last few years, oncology research and pharma development have been focused on identifying new targets (EGFR, HER2, ALK, PD-1, PD-L1) and on developing “targeted” or “immune” therapies.

It has been widely demonstrated that not all patients respond to the treatments and that responding patients relapse, some more rapidly than others. If they do, treatment options are scarcer and the tumor is usually becoming resistant and more aggressive, ultimately leading to the death of the patient.

This situation, together with a better understanding of the tumor spatio-temporal heterogeneity and progression, led oncologists to take into account all parameters and particularities of their patients’ cancer from the initial diagnosis to tumor progression.

Oncologists can now use a lot of diversified information coming from multiple technologies in order to get as much useful, clinically valuable information as they can for their patients. This is where OncoKDM, sponsored by Moncodaneum, become interesting, since their main objectives are:

  • To develop a robust ecosystem, respecting legal requirements capable of integrating all raw data coming from all technologies.
  • To provide quality control of the data before they are integrated.
  • To highlight useful information coming from the data.
  • To compare integrated data with a validated, up-to-date database
  • To provide oncologists with the most relevant report in the shortest time possible.
  • To provide oncologists with a secure data sharing environment to allow them to organize virtual molecular tumor boards and share expertise.
  • To generate a structured, dynamic database that takes account of the latest scientific breakthroughs and clinical follow-up data of the patient
  • To generate a collective intelligence system that enables oncologists to use  “patient matching”.

 

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When national heritage inspires a high-tech project

OncoDNA-Moncodaneum

©2017 Mundaneum

The name of the project is a combination of “Mundaneum and oncology”. The Mundaneum was created in 1910, following an initiative launched in 1895 by Belgian lawyers Paul Otlet and Henri La Fontaine, as part of their work on documentation science.

It was located in Brussels and Otlet first called it the Palais Mondial, which means “World Palace” in English. It aimed to gather together all the world’s knowledge and classify it according to a system they developed called the Universal Decimal Classification. Otlet and La Fontaine organized a Conference of International Associations which was the origin of the Union of International Associations (UIA).

The Mundaneum has been identified as a milestone in the history of data collection and management, and perhaps even a precursor to the Internet.

Otlet regarded the project as the centerpiece of a new ‘world city’—a centerpiece which eventually became an archive with more than 12 million index cards and documents. Some consider it a forerunner of the Internet (or, perhaps more appropriately, of systematic knowledge projects such as Wikipedia and WolframAlpha), and Otlet himself had dreams that one day, somehow, all the information he collected could be accessed by people from the comfort of their own homes.

 

More about Mundaneum