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A complete solution integrating the analyses of solid and liquid biopsies

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OncoSTRAT&GO Solution

Through an integrated approach combining DNA and protein profiling of the tumor with heterogeneity detection in the ctDNA, OncoSTRAT&GO can establish a complete genetic profile of the tumor which can be used to identify response to targeted therapies and also to classic chemotherapies and novel immunotherapies.

Description

OncoSTRAT&GO combines the analysis of a solid biopsy sample (from the primary tumor or a metastasis) and the analysis of a liquid biopsy (from a blood sample).

Analysis of the solid tumor includes the sequencing of more than 200 genes linked to approved targeted therapies This gene panel is based on the one used for the NCI-MATCH trial and was first selected for its scientific relevance: important pathways, signaling cascades, tumor metabolism, apoptosis, growth factors and DNA repair. After the first validation process, we improved the panel to cover some missing regions, added extra genes and compensated for some issues with the robustness of some amplicons due to the quality of the DNA. Additionally, we analyze the tumor RNA to detect the presence of fusion transcripts, markers also often linked to treatment resistance or susceptibility to targeted therapies.

Besides the sequencing analysis which has been shown to reveal the identity of the tumor only partially, we perform additional analyses giving critical, non-redundant information using technologies like IHC and phospho-IHC, studying microsatellite instability, unusual and damaging splicing mRNA and methylation of genes. Through this unique, integrated approach OncoSTRAT&GO can establish a complete genetic profile of the tumor which can be used to identify response to targeted therapies and also to classic chemotherapies and novel immunotherapies.

Download the product sheet

Download the genes panel

Advantages

In the case of metastatic cancer patients it is essential to decipher the heterogeneity of their tumor and its related metastases. To meet this need, OncoSTRAT&GO includes the sequencing of 40 genes on the circulating tumor DNA (ctDNA) isolated from a blood sample. The blood sample can be collected at the same time as the solid biopsy sample or later when the test is ordered for the patient.

This innovative coupled analysis overcomes rebiospy issues and  opens doors to the personalized monitoring of the disease.

OncoSTRAT&GO is designed to be used in adults with metastatic or unresectable solid cancers for which treatment protocols are limited, in patients treated with targeted therapies where hotspots of resistance must be found to access 2nd and 3rd generation treatments  and/or when treatment and careful response monitoring are highly desirable.

It has recently been improved to help predict immunotherapy response better.

 

Logistics

Turnaround time for OncoSTRAT&GO is 10 working days. Just send us a block or 20 x 5 μm sections on Superfrost Plus™ slides and a blood sample (2 Streck tubes each containing 10 ml).

Download sample prep protocol

How much does OncoSTRAT&GO cost?

Suggested price

4990 EUR

Country-specific price differences

The price indicated here is the recommended retail price. It can however vary from one country to another, depending on different factors like importation fees, freight costs, currency exchange rates, …
For more info or to order this product in your region, please contact our local representative.

Reimbursement statement

Our tests are currently reimbursed in a growing number of countries. In the United Kingdom, OncoSTRAT&GO is reimbursed for patients insured by BUPA Global Insurance, using code 7331B. Other countries, like Spain, Chili, South Africa and Poland, also cover the cost of our tests, either totally or partially. Don’t hesitate to contact us for more information.

Read more about reimbursement in the UK

How to get OncoSTRAT&GO?

Ordering a solution is very simple: Just log on to OncoSHARE and select your solution(s). If you don’t have a kit, we’ll send you one. After interpretation by our expert team an interactive report will be available for you on OncoSHARE. You can review, edit and/or share it.

See more about OncoSHARE

Order an OncoSTRAT&GO
The case report

Alicia, 49 years old when diagnosed

Was given the OncoDEEP solution following a stage 3 lung cancer.

View Alicia's report