OncoKDM is an online platform that turns your NGS data into actionable clinical information. Moreover, OncoKDM can integrate NGS results with IHC, MSI and TMB data. The resulting comprehensive and interactive report includes updated information about approved and investigational treatments for each patient, as well as NGS quality control data, patient clinical data and comprehensive NGS variants annotation.
• AmpliSeq for Illumina BRCA Panel
• AmpliSeq for Illumina Cancer Hotspot Panel V2
• AmpliSeq for Illumina Focus Panel
• AmpliSeq for Illumina Comprehensive Cancer Panel
• TruSight Tumor 15
• TruSight Tumor 170
• TruSight Oncology 500
• OncoMINE Focus Assay
• OncoMINE Comprehensive Assay
• OncoMINE BRCA Assay
• Human Breast Cancer Panel
• Human Colorectal Cancer Panel
• Human Lung Cancer Panel
• Human Actionable Solid Tumor Panel
• Human BRCA 1 & 2 Plus Panel
Any panel starting from the VCF files
ClearSeq Comprehensive Cancer Panel
The rapidly evolving field of personalized oncology requires to be constantly aware of scientific updates regarding drug responses, changes in guidelines, recruiting clinical trials... OncoKDM transforms the test results coming from the lab into actionable clinical information in the form of a report that includes clinical recommendations about approved or investigational drugs in a personalized way.
Combining the results of different molecular profiling tests with clinical data is key to select the best therapy options. OncoDNA can combine all this information into its powerful platform OncoKDM. Pathologists and biologists can upload the data into OncoKDM, and the platform will turn them into actionable clinical information in the form of a report. This report contains all the mutations found, IHC markers, and TMB and MSI status, among others, and the related drugs.
Patient-centric, OncoKDM platform gathers data such as medical information and patient history.
Next-generation sequencing analysis encompasses smart variant classification including biological and therapeutical impacts, CNV analysis and coverage and uniformity quality control at the exon level (not possible for VCF files).
Drugs associated with potential clinical benefit or to avoid based on official guidelines and clinical evidences.
You can include additional testing such as protein expression, translocations, unusual splicing or methylation.
The immunogram shows the potential response of each patient to immunotherapy. It is created from (1) the percentage of PD-L1-positive tumour cells, (2) the percentage of infiltrated CD8+ T cells, (3) the level of tumour mutational burden, (4) the microsatellite stability status of the tumour, and (5) the presence of mutations associated with either sensitivity or resistance to immunotherapy.
The larger the area, the better the patient should respond to immunotherapy.
We report recruting clinical trials worldwide based on the patient's specific molecular profile.
The comprehensive summary reports all conclusions including the key findings, a simplified pathway analysis and the treatment recommendations based on molecular and clinical evidence.
The report is supported by a list of key scientific papers that have been used to build up the personalised patient report.
OncoKDM provides you with up-to-date biological and clinical interpretation of your NGS oncology data.
You simply need to upload your data to our platform in a few clicks.
Upload your FASTQ, BAM or VCF files
A batch of samples can be uploaded in one click, meaning that you will not waste your time uploading the samples one by one
It takes up to 48 hours to interpret your data
OncoKDM is ISO 13485:2016 certified. This ISO norm specifies the requirements for quality management systems (QMS) in the medical device industry. Being certified indicates that the OncoDNA quality management system meets the most recent regulatory and quality requirements in the field of medical devices. The ISO 13485:2016 norm also describes the requirements for the management of information security and helps the company to meet GDPR (General Data Protection Regulation) compliance.
OncoKDM platform is operating in an ISO 27001 environment. Hence, the data management and security are fullly compliant with the highest standards to keep information assets secure. The international standard ISO 27001 is awarded to a company for best practices for information security management systems. Compliance with these standards demonstrates OncoDNA commitment to a repeatable, continuously improving, risk-based security program. The management system was inspected by the International Certification Trust Services (Icts)
May 18, 2019, noon
Feb. 7, 2019, 11 a.m.
Given the expertise of OncoDNA in delivering solutions in precision medicine, we initiated this collaboration with enthusiasm with the aim of developing a specific SOLTI OncoKDM solution integrating any kind of molecular data that might reveal unappreciated vulnerabilities in the tumours of AGATA patients, allowing us to tailor much better their treatment options.
Compared to its competitors, OncoKDM includes patient-centred features that enable oncologists to recommend and make the right treatment decisions according to patient's data and medical history. Moreover, OncoKDM is user-friendly and easy to use, another advantage!
OncoKDM can analyse NGS data from RNA fusion and DNA panels, as well as assess MSI (microsatellite instability), TMB (tumour mutational burden), LOH (loss of heterozygosity), copy number variations, etc. Note that we do not currently analyze whole transcriptome data, RNA-Seq differential expression data, RNA data from Ion Torrent, or germline mutations.
OncoKDM is compliant with ISO/IEC 27001:2013 (information security management systems) and ISO 13485:2016 (medical devices quality management). OncoKDM is also GDPR- and GCP-compliant.
No, OncoKDM is a platform focused on the interpretation of somatic alterations.
The knowledge database is generated by manually reviewing publicly available scientific data (i.e. scientific publications, conference abstracts...). A member of the scientific team extracts the relevant information and adds it to the database. After this step, there is always a validation step by a second member of the team.
If your question is not included in the list above or you would like more information about our solutions, please contact us at firstname.lastname@example.org. Our Patient and Scientific Support teams are available to answer your questions from Monday to Friday. You can also reach us through the chat (icon at the bottom right corner of current window).